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Sunday, March 24, 2013

Hyperkin Retron 5 plays the cartridges of nine classic consoles (video)

Hyperkin has developed a reputation for modern takes on legendary game consoles that are often better than the real thing. If true, its just-unveiled Retron 5 is a nostalgia singularity. The hardware emulator can use its namesake five cartridge slots to play original games from no less than nine vintage consoles, including the Genesis (Megadrive), NES (Famicom), SNES (Super Famicom) and GameBoys from the original through to the GameBoy Advance. It keeps going: there's a custom Bluetooth controller that can handle every system, mix-and-match original controller support, save states and upscaling for both video (to 720p, through HDMI) as well as audio. While we'll have to see just how well the Retron 5 works whenever it exists as more than a conceptual graphic, that opportunity may come quickly when Hyperkin is tentatively shooting for a July release at less than $100. About all that's left for a follow-up Retron are Jaguar and Turbografx 16 slots -- pretty please?

Filed under: Gaming, Nintendo

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Source: Hyperkin

Source: http://www.engadget.com/2013/03/24/hyperkin-retron-5-plays-cartridges-of-nine-classic-consoles/

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Ohio prosecutor indicts 'Punxsutawney Phil' for meteorological fraud

An Ohio prosecutor indicted 'Punxsutawney Phil' today for felony misrepresentation of spring. The groundhog deliberately misled the public to think winter was on its way out, and now the Ohio prosecutor is calling for the rodent's death.?

By Staff,?Associated Press / March 22, 2013

An Ohio prosecutor indicted Punxsutawney Phil today and called for his death. The rodent was last seen here, Feb. 2., after predicting ? fraudulently, the Ohio prosecutor says ? an early spring.

Keith Srakocic / Associated Press

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Famed groundhog Punxsutawney Phil might want to go back into hibernation.

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Authorities in still-frigid Ohio have issued an "indictment" of the furry rodent, who predicted an early spring when he didn't see his shadow after emerging from his western Pennsylvania lair on Feb. 2.

"Punxsutawney Phil did purposely, and with prior calculation and design, cause the people to believe that spring would come early," Mike Gmoser, the prosecutor in southwestern Ohio's Butler County, wrote in an official-looking indictment.

Gmoser wrote that Punxsutawney Phil is charged with misrepresentation of spring, which constitutes a felony "against the peace and dignity of the state of Ohio."

The penalty Phil faces? Gmoser says ? tongue firmly in cheek ? is death.

Punxsutawney Phil does not have a listed phone number.

Bill Deeley, president of the Punxsutawney club that organizes Groundhog Day, said Phil has a lawyer and would fight any extradition attempt by Ohio authorities.

Deeley defended his fur-bearing associate and said the death penalty was "very harsh" given the nature of the allegations.

"We'll have to plead our case one way or the other, but I think we can beat the rap," Deeley said.

The vitriolic backlash on social media to Phil's dead-wrong prognostication has not gone unnoticed in and around Gobbler's Knob, Deeley said, and special security precautions were in place.

"Right next to where Phil stays is the police station," he said. "They've been notified and they said they will keep watching their monitors."

Winter has been dragging on in the Buckeye State and surrounding areas, with daily high temperatures this week hovering in the mid-30s and no end in sight for about 10 days, said Don Hughes, a meteorologist with the National Weather Service in Wilmington, Ohio.

A storm moving into the region Sunday could bring between 4 and 8 inches of snow, he said.

"It's taking too long," Hughes said, adding that he's hearing plenty of complaints from colleagues and neighbors about the late spring. "Most people I've talked to say they've had enough. They want spring. They're looking for colors and sunshine and Easter lilies."

The frigid temperatures and snow might be particularly hard to swallow after last spring, when the US saw the warmest March in recorded history. Highs in the Cincinnati area, for instance, were well into the 80s.

Hughes said this spring isn't nearly the coldest on record but that the area is about 5 degrees below normal.

Gmoser's indictment made no mention of a possible co-conspirator in the false prediction of early spring, Ohio's own forecasting groundhog, Buckeye Chuck.

Chuck also failed to see his shadow when he emerged from his burrow on Feb. 2 in Marion in north-central Ohio.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/l3cAlnn157w/Ohio-prosecutor-indicts-Punxsutawney-Phil-for-meteorological-fraud

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Saturday, March 23, 2013

Atherosclerosis: Specific microRNAs promote inflammation

Mar. 22, 2013 ? Atherosclerosis, an inflammatory reaction, is at the root of the most common forms of cardiovascular disease. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a microRNA that plays a prominent role in the process, and offers a promising target for new therapies.

Atherosclerosis -- otherwise known as hardening of the arteries -- is a prevalent cause of death in modern societies. The condition arises from the build-up of localized fatty deposits called plaques in the arteries. Macrophages, the phagocytic cells of the immune system, migrate to these sites, inducing chronic inflammation which exacerbates the accumulation of the atherosclerotic lesions. These can lead to obstruction of major vessels, causing heart attack and stroke. A team of medical researchers led by LMU's Professor Andreas Schober has now identified a microRNA (miRNA) that helps initiate the inflammatory process.

miRNAs are short segments of RNA derived from longer precursors transcribed from defined stretches of the genomic DNA. They act as versatile regulators of gene expression in cells, and also control the function of macrophages, in which patterns of gene activity must respond rapidly to changes in the extracellular environment. "However, the miRNAs that control the inflammation process during the various stages of atherosclerosis had not been identified up to now," says Schober.

In an earlier study, Schober and his team had shown that the microRNA miR-155 is a prominent member of the miRNA population in macrophages. The molecule prevents the synthesis of a protein that inhibits the inflammatory reaction, and thus promotes the progression of atherosclerosis. However, miR-155 does not serve as the initiator of inflammation. Schober and his colleagues have now looked at the patterns of microRNA expression in atherosclerotic lesions in the mouse, and noted that levels of a different miRNA, called miR-342-5p, increase in very early plaques.

New therapeutic approaches "The newly identified miR-342-5p is actually expressed constituently in macrophages, but it is activated by pro-inflammatory signals. This activation process then induces production of miR-155," Schober explains. The results of the new study thus make miR-342-5p an interesting target for new therapeutic agents. Indeed, in their animal model, the researchers have been able to demonstrate that inhibition of the action of miR-342-5p by means of a specific antagonist retards the progression of atherosclerosis.

"Atherosclerosis in humans should also be susceptible to treatment with inhibitors of microRNAs," Schober suggests. "Synthetic inhibitors are available for each and every microRNA, and could be used for therapeutic purposes as soon as their efficacy and safety has been demonstrated in clinical tests." Hence the researchers now plan to collaborate with biotechnology companies on the development of their own specific microRNA inhibitor for future clinical use.

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The above story is reprinted from materials provided by Ludwig-Maximilians-Universit?t M?nchen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Y. Wei, M. Nazari-Jahantigh, L. Chan, M. Zhu, K. Heyll, J. Corbalan-Campos, P. Hartmann, A. Thiemann, C. Weber, A. Schober. The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155-Dependent Pathway during Atherosclerosis. Circulation, 2013; DOI: 10.1161/CIRCULATIONAHA.112.000736

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/nBzLn2LzZ4w/130322125347.htm

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IRS calls 'Star Trek' parody video a mistake

WASHINGTON (AP) ? Nobody's going to win an Emmy for a parody of the TV show "Star Trek" filmed by Internal Revenue Service employees at an agency studio in Maryland.

Instead, the IRS got a rebuke from Congress for wasting taxpayer dollars.

The agency says the video, along with a training video that parodied the TV show "Gilligan's Island," cost about $60,000. The "Star Trek" video accounted for most of the money, the agency said.

The IRS said Friday it was a mistake for employees to make the six-minute video. It was shown at the opening of a 2010 training and leadership conference but does not appear to have any training value.

The video features an elaborate set depicting the control room, or bridge, of the spaceship featured in the hit TV show. IRS workers portray the characters, including one who plays Mr. Spock, complete with fake hair and pointed ears.

The production value is high even though the acting is what one might expect from a bunch of tax collectors. In the video, the spaceship is approaching the planet "Notax," where alien identity theft appears to be a problem.

"The IRS recognizes and takes seriously our obligation to be good stewards of government resources and taxpayer dollars," the agency said in a statement. "There is no mistaking that this video did not reflect the best stewardship of resources."

The agency said it has tightened controls over the use of its production equipment to "ensure that all IRS videos are handled in a judicious manner that makes wise use of taxpayer funds while ensuring a tone and theme appropriate for the nation's tax system."

The agency also said, "A video of this type would not be made today."

The video was released late in the day Friday after investigators from the House Ways and Means Committee requested it.

"There is nothing more infuriating to a taxpayer than to find out the government is using their hard-earned dollars in a way that is frivolous," said Rep. Charles Boustany, R-La., chairman of the Ways and Means oversight subcommittee. "The IRS admitted as much when it disclosed that it no longer produces such videos."

The film was made at an IRS studio in New Carrollton, Md., a suburb of Washington. The agency said it uses the studio to make training films and informational videos for taxpayers.

"The use of video training and video outreach through the in-house studio has become increasingly important to the IRS to reach both taxpayers and employees," the agency said. "In the current budget environment, using video for training purposes helps us save millions of dollars and is an important part of successful IRS cost-efficiency efforts."

IRS YouTube videos have been viewed more than 5 million times, the agency said. A video on the IRS website called "When Will I Get My Refund?" has been seen 950,000 times this filing season.

The disclosure of the "Star Trek" video comes as agencies throughout the federal government face automatic spending cuts, including employee furloughs at many of them.

Acting IRS Commissioner Steven Miller has told employees they could be furloughed five to seven days this summer. The furloughs, however, will be delayed until after tax filing season so refunds should not be affected.

The agency said the "Star Trek" video "was a well-intentioned, light-hearted introduction to an important conference during a difficult period for the IRS."

Congressional investigators initially sought both the "Star Trek" video and the "Gilligan's Island" video but after viewing them determined that the "Gilligan's Island" video was a legitimate training video. The IRS did not release the "Gilligan's Island" video.

"The video series with an island theme provided filing season training for 1,900 employees in our Taxpayer Assistance Centers in 400 locations," the IRS said. "This example of video training alone saved the IRS about $1.5 million each year compared to the costs of training the employees in person."

___

Online:

http://www.youtube.com/watch?v=dHe-zXm17Pc

___

Follow Stephen Ohlemacher on Twitter: http://twitter.com/stephenatap

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-22-US-IRS-Star-Trek-Video/id-f4a95eb429bf4b278ebc6d256931a667

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Dell Optiplex 9010 AIO

Though Windows 8 and new touch-enabled PCs have largely been seen in the consumer space, fewer equivalent business PCs have come out. Well, Dell is here to help fix the problem with the new Optiplex 9010 AIO, an all-in-one touch-screen desktop made for offices large and small. Compared with, say, graphics-oriented workstations it may not impress, but it's still a powerful system. With a Core i7 processor and speedy solid-state drive, the Dell Optiplex 9010 is fast and offers solid performance at a price that even small businesses can afford, making it our Editors' Choice for all-in-one business desktops.

Design and Features
The 9010's design places an emphasis on the touch-capable monitor, which offers a 23-inch TN panel with a 1,920-by-1,080 resolution that looks good from most any angle. The touch-screen offers 10-digit input, and the entire display is covered with edge-to-edge glass. The OptiPlex 9010 features the same dual hinge stand seen on the mainstream consumer Dell XPS One 27 Touch. The two-hinge design allows easy adjustment of both height and angle, letting you position the screen just so?an important feature for any system that has you reach out and touch the screen now and then.

The chassis is utilitarian in its looks, but not unpleasantly so, with rounded corners, a glossy black bezel around the display, and a chin below that contains the system's Realtek HD Audio speakers. Above the display is a built-in webcam, but it comes with a twist?it swivels, letting you shutter the camera when not in use.

The OptiPlex 9010 also comes with a wireless keyboard and mouse. The two peripherals use a wireless USB receiver, slipped discreetly into one of the USB 2.0 ports on the back of the PC. While many typists will want to switch these out for their preferred mouse and mechanical keyboard, the bundled devices will do the trick just fine.

On the rear panel you'll find the power connector, VGA out and HDMI out for connecting to a second monitor or HDTV, Gigabit Ethernet, six USB 2.0 ports, and two PS/2 ports for use with older keyboards and peripherals. The PS/2 ports are especially helpful in business settings, where important equipment may only be available with older connections.

Ports on the back are numerous but not necessarily convenient. The back connector panel is located directly behind the dual-hinge stand, which necessitates turning the entire PC around to access many of the ports, as well as requiring more complicated cord management. Ideally, these ports could be shifted to the sides, or placed on the base. Already found on the sides of the chassis are two USB 3.0 ports and a tray-loading DVD+-RW drive.

Inside, the OptiPlex 9010 AIO features Intel Centrino Advanced-N 6235 wireless networking, Bluetooth 4.0 + HS for all of your headset and phone pairing needs, and a 128GB solid-state drive (SSD). While the drive may offer zippy performance, the overall capacity if fairly small for a work machine, with only 77GB of free space available. This is despite the fact that aside from Windows 8 Pro, the only additional software installed on the OptiPlex is Microsoft Office 2010 Starter, CyberLink Media Suite, Dell's Backup and Recovery tool, and a brief tutorial "Getting Started with Windows 8." While offices that store things on a shared server won't worry much about it, those who rely on the SSD for programs and file storage may feel the pinch sooner than expected. Dell covers the OptiPlex 9010 AIO with a three-year warranty and free on-site service.

Performance
Dell OptiPlex 9010 AIO The OptiPlex 9010 offers solid performance, thanks to a 3.1GHz Intel Core i7-3770S quad-core processor and 8GB of RAM. It's the same processor found in the Lenovo ThinkCentre M92z, and Dell's mainstream XPS One 27 Touch. The resulting performance is superb, completing PCMark 7 with 4,306 points, putting it well ahead of most business AIO competitors, like the Lenovo M92z (3,872) and Lenovo Edge 91z (1,948), not to mention giving it a solid lead over the previous Editors' Choice, the Lenovo ThinkCentre M71z (2,134). Cinebench scores were equally impressive, with the hyper-thread quad-core processor producing a score of 6.98 points, nearly matching the top performers in the category, the HP Envy 23-d060qd TouchSmart and the Lenovo ThinkCentre M92z (7.06 and 7.00, respectively).

The one area where the OptiPlex fell through was graphics. The integrated Intel HD Graphics 4000 provide a solid solution for professionals who don't depend upon design or modeling programs, but our tests show that anyone needing to run CAD or a similar program will need to look for something with a discrete card. Despite the lack of graphics horsepower, the OptiPlex 9010 should still perform well in multimedia tasks, as it cranked through Handbrake in 33 seconds and Photoshop CS6 in 3 minutes 31 seconds.

Conclusion
Whether for a small business or a large corporation, the Dell Optiplex 9010 AIO offers the best of Windows 8, merging solid performance with intelligent design and full-featured touch capabilities. As such, it replaces the Lenovo ThinkCentre M71z as our latest Editors' Choice for all-in-one business desktops.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/ArP8qKDM5l0/0,2817,2416970,00.asp

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Movie review: 'Stoker' goes wild with Hitchcock style | The Salt Lake ...

Evelyn (Nicole Kidman, left) and her daughter India (Mia Wasikowska) mourn India's father Richard in the thriller "Stoker." Courtesy Fox Searchlight

When you?re going to rip off Hitchcock, you might as well go for it with both feet ? as Korean director Park Chan-Wook does in his first Hollywood film, the eerie thriller "Stoker."

When the patriarch of the Stoker clan, Richard (Dermot Mulroney), dies in a mysterious car accident, the news hits his wife, Evelyn (Nicole Kidman), hard. But their awkward daughter, India (Mia Wasikowska), who turned 18 on the day of the accident, takes it harder. Evelyn and India have little time to mourn when Richard?s long-absent brother Charlie (Matthew Goode) arrives, stirring the loins of mother and daughter. But India starts to see Uncle Charlie?s dark side and is both repulsed by it and attracted to him.

Park (who directed the Korean classic "Oldboy") amps up every moment with a sweaty, ghoulish atmosphere, and he plants the Hitchcock references like an Easter egg hunt. There are a plot point from "Shadow of a Doubt" and swinging light fixtures out of "Psycho," among other things. But Park?s bravura directing moves, while giving Kidman and Wasikowska some meaty scenes to chew up, cover the glaring story holes that screenwriter Wentworth Miller (yes, the actor from "Prison Break") leaves all over the field.

movies@sltrib.com; www.sltrib.com/entertainment

Source: http://www.sltrib.com/sltrib/entertainment2/56024725-223/india-park-hitchcock-stoker.html.csp

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Friday, March 22, 2013

When Buying Luxury Bath Products | Jackie's Women's Interest Bazaar

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If you are looking for quality luxury bath products, the one thing that you should know is that they do not need to be expensive. They only need to be quality to give you that worth for your money. Any good buys always translate to having good quality at an excellent price that is within the range of your affordability.

There are affordable beauty products available in the market today. They can be found in trade shows, craft shows, in your favorite cosmetic stores and in online shops. No matter where you decide to buy your merchandise, make sure that the store is reputable.

You can also ask friends and colleagues where they think is a good store to buy luxury body washes from. In fact, you can even ask them about the goods they use in caring for their skin. They can share with the beauty goods that they utilize for themselves and their family and tip you off about the a good store where they buy it from.

It is important for them to have a robust payment system for their customers. Customers confidential payment details need to remain confidential. They need to be protected from identity theft, which usually results in online transactions.

You should learn also about their returns policy. Make sure that you know they have one. This is needed because there might be problems with the purchase. If you want the goods to be exchanged with another one, you should know when you need to get the items shipped back and process the cancellation of the original order from the date your first received the items.

This is advantageous both to the business and the customers who are patronizing their service. Customers can now access their store even if it is beyond business hours. These online shops are literally opened 24 hours a day, seven days a week.

They do not go off the radar when the clock strikes at five in the afternoon. Orders can be filed online by filling an online form. Expect your transaction to be processed right away or in the next business day.

In fact stores that only exist in malls and on the streets have now online versions of them. They have now their online shops, which is good because people who do not have time to go to their boutiques can just check their selection online. That is very convenient for their customers and the same time a profitable venture for them. It is profitable because customers can place order of luxury bath products anytime, anywhere.

If you would like to find a great source for luxury bath products click this link. You will find a wide variety of affordable beauty products when you shop with us today.