Wednesday, April 3, 2013

Panetta says US must be 'very firm' with N. Korea as it issues more threats

As the U.S. deploys a Navy missile destroyer in case of a launch by North Korea, the country's leader Kim Jong Un has abolished an armistice with South Korea and is now saying he will re-open a nuclear bomb facility that was closed in 2007. NBC's Richard Engel reports.

By Ian Johnston and Jim Miklaszewski, NBC News

Former Defense Secretary Leon Panetta has warned that the United States should be ?very concerned? by the level of ?provocation and bellicosity? emanating from North Korea, as the rogue communist state announced it was going to restart all its nuclear facilities.

Panetta told CNBC in an interview that the U.S., Japan and South Korea had to be ?very firm in sending them a message that we are going to do everything necessary to defend our security and defend our troops.? He said there was a danger of a "miscalculation" that escalated.

The North continued to make threats Tuesday, and said it would rebuild and restart nuclear facilities, including a reactor that can make one bomb's worth of plutonium a year.

Panetta said the amount of hostility emanating from Pyongyang was alarming.

?I think we've got to be very concerned about ... the level of provocation that North Korea is engaged in. They are in the process of testing ICBMs [Intercontinental Ballistic Missiles]. They've also been testing nuclear weapons,? he said.

NBC's Jim Maceda reports on U.S. Navy movements of destroyers into the Pacific amid threats from North Korea.

?The kind of provocation and bellicosity they're showing now with their rhetoric raises a lot of concern,? he added. ?It just means the United States and our allies Japan and South Korea have to be very firm in sending them a message that we are going to do everything necessary to defend our security and defend our troops.?

United Nations Secretary-General Ban Ki-moon took time out of an official visit to Andorra on Tuesday to say that the North Korean crisis had "already gone too far" and that he was "deeply troubled" by it.

"Nuclear threats are not a game," Ban said, adding that "things must begin to calm down" or they "could lead down a path that nobody should want to follow."

He closed his remarks by offering to facilitate peace talks, but how the North would react was not immediately clear. Ban was South Korea's foreign affairs minister before election to his UN post.

'Be very prepared'
Panetta noted that over the last 50 or 60 years the North had gone through cycles of ?provocation? and ?accommodation.?

?A lot of this is aimed more probably on the internal situation in North Korea, aimed at improving the new leader's credibility, his credentials as a leader,? he said.

?But at the same time since they have capabilities and [are] developing those capabilities, I don't think we can take anything for granted. The U.S., South Korea and our other partners in that region have to be very prepared in the event that something could happen here. I think the greater likelihood is miscalculation and if they do something that escalates quickly that's the greater danger,? he added.

A spokesman for the North's General Department of Atomic Energy said restarting its nuclear facilities was part of efforts to resolve the country's acute electricity shortage, but also for "bolstering up the nuclear armed force both in quality and quantity," the official Korean Central News Agency said, according to Reuters.

Pyongyang conducted its third nuclear test in February, prompting a new round of U.N. sanctions that have infuriated its leaders and led to a torrent of threatening rhetoric. The United States has sent nuclear-capable bombers and stealth jets to participate in annual South Korean-U.S. military drills that the allies call routine but that Pyongyang claims are invasion preparations.

As North Korean state TV shows constant images of the army bombarding South Korea, North Korea's leader Kim Jong Un is saying his missiles are at the ready and has cut off emergency communications. NBC's Richard Engel reports.

KCNA kept up the rhetoric on its English-language site Tuesday, with an article headlined ?Intensified Anti-U.S. Action Called For.?

It quoted the ?North Side Committee for Implementing the June 15 Joint Declaration? as saying in a statement that the joint U.S. and South Korean military exercise ?clearly proves that the U.S. imperialists' scenario to launch a nuclear war on the Korean Peninsula at any cost has reached an extremely reckless phase of its implementation.?

?As already clarified by the DPRK [North Korea], gone are the days when it could have verbal exchange with them,? the statement said.

?To wage a merciless, just, retaliatory war is the only way of rooting out the source of the danger of a nuclear war on this land and build a peaceful and prosperous reunified thriving nation where all Koreans live together,? it added.

Reuters and NBC News' Andrea Mitchell and John Newland contributed to this report.

Related:

US Navy shifts destroyer in wake of North Korea missile threats

US official warns North Korea is no 'paper tiger'

Analyst: Threats are predictable, Kim Jong Un is not

This story was originally published on

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Tuesday, April 2, 2013

Minube's Trip Planning Feature Just Got A Lot More Social, iOS App Gets Real-Time Messaging

MinubeMinube, the social travel startup that focuses on inspiration for would-be travellers, has rolled out a nice update to the trip planning feature of its iOS app. After creating and sharing a list of things to do and see or where to stay or eat -- which works like a draft itinerary -- any friends or co-travelers who have been granted access to that list can now message each other in real-time, making it a lot easier to communicate with the group, especially when plans typically change. In this context, Minube's travel list making feature has the potential to become a hub of activity not just at the planning stage of a trip, but also during the trip itself.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/UIdv9H-GMeQ/

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Investigational vaccine not effective in reducing post-operative staph infections

Investigational vaccine not effective in reducing post-operative staph infections [ Back to EurekAlert! ] Public release date: 2-Apr-2013
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
The JAMA Network Journals

Use of a vaccine to prevent Staphylococcus aureus infections among patients undergoing cardiothoracic surgery did not reduce the rate of serious postoperative S aureus infections compared with placebo and was associated with increased mortality among patients who developed S aureus infections, according to a study in the April 3 issue of JAMA.

Infections with S aureus following median sternotomy (incision through the midline of the sternum) cause substantial illness and death. "A safe vaccine that provides protection against a majority of S aureus strains during the postoperative period would address an important unmet medical need," according to background information in the article. A novel vaccine candidate (V710) is immunogenic and generally well tolerated in volunteers, with elevated antibody responses persisting for at least 1 year after vaccination in most patients.

Vance G. Fowler Jr., M.D., M.H.S., of Duke University Medical Center, Durham, N.C., and colleagues conducted a phase 2b/3 study to evaluate the efficacy and safety of preoperative V710 vaccination in preventing serious postoperative S aureus infection in patients undergoing cardiothoracic surgery. The randomized trial was conducted between December 2007 and August 2011 among 8,031 patients 18 years of age or older who were scheduled for full median sternotomy within 14 to 60 days of vaccination at 165 sites in 26 countries. Participants were randomly assigned to receive a single intramuscular injection of either V710 vaccine (n=4,015) or placebo (n=4,016).

The independent data monitoring committee recommended termination of the study after the second interim analysis because of safety concerns and low efficacy. In the primary modified intention-to-treat analysis, V710 vaccine was not significantly more efficacious than placebo in preventing the prespecified primary end point (S aureus bacteremia and/or deep sternal wound infection through postoperative day 90) (22 adjudicated cases in 3,528 evaluable V710 recipients vs. 27 adjudicated cases in 3,517 evaluable placebo recipients). No significant differences in efficacy between the vaccine and placebo groups were observed at any point during the study.

The researchers also found that the V710 vaccine was not significantly more efficacious than placebo in preventing the secondary end points (all S aureus surgical site and invasive infections through postoperative day 90).

Compared with placebo, the V710 vaccine was associated with more adverse experiences during the first 14 days after vaccination (30.8 percent vs. 21.8 percent), including injection site reactions (20.1 percent vs. 9.5 percent) and serious adverse events (1.7 percent vs. 1.3 percent), and a significantly higher rate of multiorgan failure during the entire study (31 vs. 17 events).

Although the overall incidence of vaccine-related serious adverse events (1 in each group) and the all-cause mortality rate (201/3,958 vs. 177/3,967) were not statistically different between groups, the mortality rate in patients with staphylococcal infections was significantly higher among V710 vaccine than placebo recipients (15/73 vs. 4/96).

"In our study of adult patients undergoing cardiothoracic surgery, preoperative vaccination with V710 did not significantly reduce the composite incidence of S aureus bacteremia and deep sternal wound infection," the authors write. "These findings do not support the use of the V710 vaccine for patients undergoing surgical interventions."

###

Editor's Note: The study was sponsored and funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., Whitehouse Station, New Jersey. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

Editorial: Preventing Postoperative Staphylococcus aureus Infections - The Search Continues

Preeti N. Malani, M.D., M.S.J., of the University of Michigan Health System, Ann Arbor, Mich., (and Contributing Editor, JAMA), comments on the findings of this study in an accompanying editorial.

"While the prevention of S aureus infections should remain a priority for future investigation, novel approaches must move beyond vaccine strategiesand for that matter, beyond S aureus. Even if a viable staphylococcal vaccine were to be developed, this would not address non-S aureus infections. Burgeoning antimicrobial resistance results in an urgent, worldwide public health mandate. Progress in this arena will require expansion of preventive efforts and interventions that cover all organisms."

Editor's Note: The author has completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Investigational vaccine not effective in reducing post-operative staph infections [ Back to EurekAlert! ] Public release date: 2-Apr-2013
[ | E-mail | Share Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
The JAMA Network Journals

Use of a vaccine to prevent Staphylococcus aureus infections among patients undergoing cardiothoracic surgery did not reduce the rate of serious postoperative S aureus infections compared with placebo and was associated with increased mortality among patients who developed S aureus infections, according to a study in the April 3 issue of JAMA.

Infections with S aureus following median sternotomy (incision through the midline of the sternum) cause substantial illness and death. "A safe vaccine that provides protection against a majority of S aureus strains during the postoperative period would address an important unmet medical need," according to background information in the article. A novel vaccine candidate (V710) is immunogenic and generally well tolerated in volunteers, with elevated antibody responses persisting for at least 1 year after vaccination in most patients.

Vance G. Fowler Jr., M.D., M.H.S., of Duke University Medical Center, Durham, N.C., and colleagues conducted a phase 2b/3 study to evaluate the efficacy and safety of preoperative V710 vaccination in preventing serious postoperative S aureus infection in patients undergoing cardiothoracic surgery. The randomized trial was conducted between December 2007 and August 2011 among 8,031 patients 18 years of age or older who were scheduled for full median sternotomy within 14 to 60 days of vaccination at 165 sites in 26 countries. Participants were randomly assigned to receive a single intramuscular injection of either V710 vaccine (n=4,015) or placebo (n=4,016).

The independent data monitoring committee recommended termination of the study after the second interim analysis because of safety concerns and low efficacy. In the primary modified intention-to-treat analysis, V710 vaccine was not significantly more efficacious than placebo in preventing the prespecified primary end point (S aureus bacteremia and/or deep sternal wound infection through postoperative day 90) (22 adjudicated cases in 3,528 evaluable V710 recipients vs. 27 adjudicated cases in 3,517 evaluable placebo recipients). No significant differences in efficacy between the vaccine and placebo groups were observed at any point during the study.

The researchers also found that the V710 vaccine was not significantly more efficacious than placebo in preventing the secondary end points (all S aureus surgical site and invasive infections through postoperative day 90).

Compared with placebo, the V710 vaccine was associated with more adverse experiences during the first 14 days after vaccination (30.8 percent vs. 21.8 percent), including injection site reactions (20.1 percent vs. 9.5 percent) and serious adverse events (1.7 percent vs. 1.3 percent), and a significantly higher rate of multiorgan failure during the entire study (31 vs. 17 events).

Although the overall incidence of vaccine-related serious adverse events (1 in each group) and the all-cause mortality rate (201/3,958 vs. 177/3,967) were not statistically different between groups, the mortality rate in patients with staphylococcal infections was significantly higher among V710 vaccine than placebo recipients (15/73 vs. 4/96).

"In our study of adult patients undergoing cardiothoracic surgery, preoperative vaccination with V710 did not significantly reduce the composite incidence of S aureus bacteremia and deep sternal wound infection," the authors write. "These findings do not support the use of the V710 vaccine for patients undergoing surgical interventions."

###

Editor's Note: The study was sponsored and funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., Whitehouse Station, New Jersey. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

Editorial: Preventing Postoperative Staphylococcus aureus Infections - The Search Continues

Preeti N. Malani, M.D., M.S.J., of the University of Michigan Health System, Ann Arbor, Mich., (and Contributing Editor, JAMA), comments on the findings of this study in an accompanying editorial.

"While the prevention of S aureus infections should remain a priority for future investigation, novel approaches must move beyond vaccine strategiesand for that matter, beyond S aureus. Even if a viable staphylococcal vaccine were to be developed, this would not address non-S aureus infections. Burgeoning antimicrobial resistance results in an urgent, worldwide public health mandate. Progress in this arena will require expansion of preventive efforts and interventions that cover all organisms."

Editor's Note: The author has completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/tjnj-ivn032813.php

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Monday, April 1, 2013

PFT: Geno Smith will attend NFL Draft

GenoGetty Images

While some teams picking in the top 10 may be blowing smoke about their interest in West Virginia quarterback Geno Smith, he?s apparently willing to assume that at least one of them has rubbed the sticks together hard enough to make a flame.

Per a source with knowledge of the situation, Smith has accepted an invitation to attend the 2013 draft in New York City.

Unlike last year, when everyone knew that quarterbacks Andrew Luck and Robert Griffin III would be the first and second selections, it?s unclear when the top quarterbacks in this year?s draft pool will be plucked.? It?s still not completely clear which quarterback will go first.

A loose consensus points to Smith.? But no one will know for sure until the time comes to make the picks.

Chances are Smith will go in the top 10, as high as the Jaguars at No. 2 or possibly as low as the Jets at No. 9, with the Raiders (No. 3), the Eagles (No. 4), the Cardinals (No. 7), and the Bills (No. 8) possibly pouncing in between.

If Smith gets past No. 9, he could do a Quinn-Rodgers slide into the 20s, with a team at the top of round two likely to trade back into the first round to stop the bleeding.

The good news for Smith, if he slips, is that the NFL brings far more players to Radio City Music Hall than previously.? Even if he?s the last man taken on Thursday night, there will still be other guys in the green room, chewing gum and/or diddling the maid.

Source: http://profootballtalk.nbcsports.com/2013/03/30/geno-smith-will-attend-the-draft/related

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Fighting erupts after car bombing in Mali

By Tiemoko Diallo

BAMAKO (Reuters) - Malian soldiers backed by French fighter jets battled Islamist rebels in Timbuktu on Sunday after insurgents used a car bomb as cover to infiltrate the northern desert town, sources said.

The French-led offensive in Mali has pushed a mix of Islamists out of their northern strongholds and remote mountain bases but the militants have hit back with several suicide attacks and guerilla-style raids.

At least one Malian soldier was killed and four injured in Sunday's fighting in the ancient Saharan trading hub 1,000 km (600 miles) north of the capital Bamako, according to a Mali government communique issued on Sunday evening.

It said that 21 Islamist rebels were also killed.

"It started after a suicide car bombing around 2200, that served to distract the military and allow a group of jihadists to infiltrate the city by night," said Mali army Captain Modibo Naman Traore.

Bilal Toure, a member of Timbuktu's crisis committee set up after the town was recaptured from Islamist control in January, said he saw a French plane firing on the rebel positions. He said fighting had died down since nightfall.

"The situation settled down after around 1900 but everyone is still staying indoors," he said.

The attack reflected the challenge of securing Mali as France prepares to reduce its troop presence and hand over to the ill-equipped Malian army and a more than 7,000-strong regional African force.

Mali's defense ministry said on Saturday that two Nigerian soldiers in the regional African force were killed when their convoy struck a mine outside Ansongo, near the Niger border.

France launched its intervention in Mali in January to halt an advance by northern al Qaeda-linked rebels towards Bamako.

President Francois Hollande said on Thursday that France will reduce its troop numbers in Mali to 2,000 by July and to 1,000 by the end of the year, down from 4,000 at present.

The West African former colony is to hold presidential and legislative elections in July - vital steps to stabilizing the gold- and cotton-producer after a military coup a year ago paved the way for the northern rebel takeover.

(Reporting by Tiemoko Diallo and Adama Diarra; Writing by Richard Valdmanis; Editing by Stephen Powell)

Source: http://news.yahoo.com/fighting-erupts-car-bombing-mali-121731941.html

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Holmes to hear if prosecutors will seek death penalty

CENTENNIAL, Colo. (AP) ? After a week of legal twists and turns, James Holmes will find out Monday if he could face execution if convicted in the Colorado theater attack that killed 12 people.

Behind-the-scenes maneuvering erupted into a public quarrel between prosecutors and the defense over Holmes' public offer to plead guilty, but the two sides could still come to an agreement that would spare Holmes's life in exchange for spending the rest of his life in prison.

"Even if they give notice on Monday that they are seeking the death penalty, they can come off that and enter into a plea bargain any time," said attorney Dan Recht, a past president of the Colorado Criminal Defense Bar.

As the tangled and bloody case returns to court, survivors and families of the victims are uncertain about what happens next.

If the case goes to trial, "all of us victims would be dragged along potentially for years," said Pierce O'Farrill, who was shot three times.

"It could be 10 or 15 years before he's executed. I would be in my 40s and I'm planning to have a family, and the thought of having to look back and reliving everything at that point in my life, it would be difficult," he said.

Holmes is accused of a meticulously planning and brutally executing a plan to attack a Colorado movie theater at midnight during a showing of the latest Batman movie, killing 12 people and injuring 70.

Defense lawyers revealed in a court filing last week that Holmes would plead guilty if prosecutors allowed him to live out his days in prison with no chance of parole instead of having him put to death.

That prompted an angry response from prosecutors, who called it an attempt to gin up public support for a plea deal.

Prosecutors also said the defense has repeatedly refused to give them the information they need to evaluate the plea agreement.

Prosecutors want to know how persuasive an insanity case Holmes could make before they agree to give up the death penalty, said Mimi Wesson, a professor at the University of Colorado Law School.

"To the prosecution, it's clear what they're giving up, but less clear what the defendant is giving up, because it's hard to know how strong his claim of insanity might be," she said.

If prosecutors do accept a deal, they will want to ensure that it's air-tight, said Karen Steinhauser, a former prosecutor who is now an adjunct professor at the University of Denver law school.

Holmes would give up his right to appeal by pleading guilty, she said. And although he could ask to change the plea if new evidence surfaces or if he claimed his lawyers were ineffective, "it's very, very hard to withdraw it," she said.

District Judge William Sylvester would want assurances from defense lawyers that Holmes is mentally competent to plead guilty and accept a life sentence with no parole, Steinhauser said.

The judge could order a mental competency evaluation before accepting a guilty plea, but Steinhauser said that's unlikely unless Holmes showed some sign of incompetence.

She said Sylvester would probably accept the word of Holmes' lawyers.

If Holmes is sentenced to prison, the state Department of Corrections would determine what kind of mental health care he gets, said Alison Morgan, a department spokeswoman.

A third of the state's inmates have moderate to severe mental illness, and the prison system has an extensive mental health division with a 250-bed facility for the acutely mental ill, she said.

Inmates can be sent to the state mental hospital in Pueblo ? where people found not guilty by reason of insanity are committed ? but the stay is temporary, and they are returned to the prison system after treatment, she said.

___

Follow Dan Elliott at http://twitter.com/DanElliottAP

Source: http://news.yahoo.com/holmes-hear-prosecutors-seek-execution-080715762.html

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NKorea says it is in a 'state of war' with SKorea

SEOUL, South Korea (AP) ? North Korea warned Seoul on Saturday that the Korean Peninsula had entered "a state of war" and threatened to shut down a border factory complex that's the last major symbol of inter-Korean cooperation.

Analysts say a full-scale conflict is extremely unlikely, noting that the Korean Peninsula has remained in a technical state of war for 60 years. But the North's continued threats toward Seoul and Washington, including a vow to launch a nuclear strike, have raised worries that a misjudgment between the sides could lead to a clash.

North Korea's threats are seen as efforts to provoke the new government in Seoul, led by President Park Geun-hye, to change its policies toward Pyongyang, and to win diplomatic talks with Washington that could get it more aid. North Korea's moves are also seen as ways to build domestic unity as young leader Kim Jong Un strengthens his military credentials.

On Thursday, U.S. military officials revealed that two B-2 stealth bombers dropped dummy munitions on an uninhabited South Korean island as part of annual defense drills that Pyongyang sees as rehearsals for invasion. Hours later, Kim ordered his generals to put rockets on standby and threatened to strike American targets if provoked.

North Korea said in a statement Saturday that it would deal with South Korea according to "wartime regulations" and would retaliate against any provocations by the United States and South Korea without notice.

"Now that the revolutionary armed forces of the DPRK have entered into an actual military action, the inter-Korean relations have naturally entered the state of war," said the statement, which was carried by Pyongyang's official Korean Central News Agency, referring to the North's official name, the Democratic People's Republic of Korea.

Provocations "will not be limited to a local war, but develop into an all-out war, a nuclear war," the statement said.

Hours after the statement, Pyongyang threatened to shut down the jointly run Kaesong industrial park, expressing anger over media reports suggesting the complex remained open because it was a source of hard currency for the impoverished North.

"If the puppet group seeks to tarnish the image of the DPRK even a bit, while speaking of the zone whose operation has been barely maintained, we will shut down the zone without mercy," an identified spokesman for the North's office controlling Kaesong said in comments carried by KCNA.

South Korea's Unification Ministry responded by calling the North Korean threat "unhelpful" to the countries' already frayed relations and vowed to ensure the safety of hundreds of South Korean managers who cross the border to their jobs in Kaesong. It did not elaborate.

South Korean Defense Ministry spokesman Kim Min-seok said the country's military remains mindful of the possibility that increasing North Korean drills near the border could lead to an actual provocation.

"The series of North Korean threats ? announcing all-out war, scrapping the cease-fire agreement and the non-aggression agreement between the South and the North, cutting the military hotline, entering into combat posture No. 1 and entering a 'state of war' ? are unacceptable and harm the peace and stability of the Korean Peninsula," Kim said.

"We are maintaining full military readiness in order to protect our people's lives and security," he told reporters Saturday.

The two Koreas remain technically at war because the 1950-53 Korean War ended in a truce, not a peace treaty. Naval skirmishes in the disputed waters off the Korean coast have led to bloody battles several times over the years.

But on the streets of Seoul on Saturday, South Koreans said they were not worried about an attack from North Korea.

"From other countries' point of view, it may seem like an extremely urgent situation," said Kang Tae-hwan, a private tutor. "But South Koreans don't seem to be that nervous because we've heard these threats from the North before."

The Kaesong industrial park, which is run with North Korean labor and South Korean know-how, has been operating normally, despite Pyongyang shutting down a communications channel typically used to coordinate travel by South Korean workers to and from the park just across the border in North Korea. The rivals are now coordinating the travel indirectly, through an office at Kaesong that has outside lines to South Korea.

North Korea has previously made such threats about Kaesong without acting on them, and recent weeks have seen a torrent of bellicose rhetoric from Pyongyang. North Korea is angry about the South Korea-U.S. military drills and new U.N. sanctions over its nuclear test last month.

Dozens of South Korean firms run factories in the border town of Kaesong. Using North Korea's cheap, efficient labor, the Kaesong complex produced $470 million worth of goods last year.

___

Follow Sam Kim at www.twitter.com/samkim_ap.

Source: http://news.yahoo.com/nkorea-says-state-war-skorea-014344604.html

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